June 19, 2020

Frontal fibrosing alopecia. Authoritative facts about the skin from DermNet New Zealand. Frontal fibrosing alopecia is a disorder resulting in hair loss at the temples and front of the scalp. Learn about the causes and treatment of FFA. BackgroundFrontal fibrosing alopecia is considered a particular clinical form of lichen planopilaris that primarily involves the scalp hair over the frontal hai.

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British Association of Dermatologists – Patient Information Leaflets (PILs)

Concomitant involvement of vellus at different body sites has recently been reported. To our knowledge, this is the first report on the involvement of facial vellus by effects of the inflammatory process. Unlike the usual noninflammatory clinical presentation of vellus involvement over other body areas, facial vellus involvement can lead to surface changes that may be recognized both by patients and dermatologists.

Histologic samples showed lichen planopilaris features involving the facial vellus. Dermatologists must learn to recognize facial surface changes and discuss these with the patients, who may attribute this roughness to aging or hormonal changes associated with menopause.

Further studies are needed to determine the prevalence of this involvement in patients with frontal fibrosing alopecia. Frontal fibrosing alopecia FFA is considered a particular ribrosing form of lichen planopilaris LPP that primarily involves the scalp hair over the frontal hairline.

Eyebrows and eyelashes can be variably affected, and alopecia sometimes develops over the axillary and pubic regions. Concomitant involvement of vellus hairs at different body sites has recently been reported 1 – 3 and indicates that FFA has a flbrosing pathologic extension.

We report on 4 cases of FFA with concomitant involvement of facial vellus. Demographics, clinical aspects, and other findings Tableas well as results of histopathologic testing of all cases, are presented. A year-old postmenopausal woman presented with frontal hairline recession that had started 3 months before her visit to the clinic; peripilar inflammation had developed in the same region. The patient had well-controlled type 2 diabetes mellitus and a 5-year history of eyebrow loss; she also reported roughening of her facial skin in the past few alopecua Figure 1 A and B.

Results of a previous scalp biopsy had shown lymphocytic and granulomatous perifolliculitis with eccentric atrophy of follicular epithelia and perifollicular fibrosis, confirming the diagnosis of FFA Figure 2 A. To study the facial alterations, a biopsy was performed over the zygomatic area and showed perifollicular lymphocytic infiltrate and fibrosis around a vellus.

Frontal Fibrosing Alopecia

Direct immunofluorescence DIF was not performed. Clinical presentation of frontal fibrosing alopecia. A, Typical inflammatory signs over the frontal hairline of patient 1.

B, Follicular papules over the right temporal region of patient 1 arrows indicate 2 follicular papules. C, Recession of hairline and papules on the right lateral face of patient 2. D, Decreased eyebrows and papules on the left temporal region of fkbrosing 3. Results of histologic testing.

A year-old black woman had developed recession of her frontal hairline, scalp pruritus, and loss of body hair after menopause, 3 years before evaluation in our clinic. She had noticed no decrease in her eyelashes or eyebrows, but her facial skin had changed during the past 5 years Figure 1 C. Biopsies of both the frontal hairline and preauricular region were performed.

Histopathologic testing of the scalp showed perifollicular fibrosis, eccentric atrophy of the follicular epithelium at the isthmus level, and foreign body reaction to the hair shaft inside the dermis. Testing of preauricular specimens showed lichenoid reaction around the follicular infundibulum and isthmus and perifollicular fibrosis Figure 2 B.


Both histologic patterns suggested LPP. Direct immunofluorescence of the scalp specimen showed moderate continuous and granulose anti-IgM fluorescence over the basement membrane and cytoid bodies in the papillary dermis.

A year-old black perimenopausal woman described loss of eyebrows and hair over the frontal hairline during the past year. A few months after the alopecic process started, she noticed progressive roughening of her facial skin Figure 1 D.

Hair on her limbs had not been present for 5 years. Biopsies were performed in 3 different sites frontal hairline, preauricular region, and right forearm.

Histologic testing of scalp specimens showed decreased follicular density, chronic perifolliculitis, and perifollicular fibrosis. Skin from her face and arm showed similar findings, also characterizing an LPP alopecic process. Direct immunofluorescence was performed on the scalp and face specimens, and the results showed no abnormalities.

A year-old white woman reported hair loss over her frontal hairline for 3 years, as well as decreased density of her eyebrows and eyelashes for 10 years.

One year before this consultation, she noticed changes of her facial skin surface and loss of hair on her arms. She attributed both of these effects to hormonal changes menopause 5 years before the visit to our clinic. Biopsies were performed on samples taken from her scalp, face, and arm. Histologic evaluation of scalp tissue detected chronic perifolliculitis with perifollicular fibrosis. The facial skin specimen showed intense lymphoplasmocytic infiltrate with complete destruction of the follicle and only remnants of the piloerector muscle and sebaceous gland Figure 2 C.

A similar infiltrate surrounding a fibrous tract could be observed in the skin specimen from the arm. Negative results of DIF testing were observed in all specimens. Frontal fibrosing alopecia is a specific form of scarring alopecia that affects the frontal hairline, most often in postmenopausal women.

Preferential involvement of vellus and intermediate hair follicles is supported by some authors. Less frequently, eyelashes and hairs in the axilla or pubic area can also be affected. Localized involvement and follicular inflammatory signs, such as patchy alopecia, have been rarely described, 9 and keratotic papules, with minimal pruritus, have been reported only once. The incidence of nonscalp vellus involvement is not known, with published data showing great variation.

To our knowledge, ours is the first report on the involvement of facial vellus of patients with FFA. The clinical picture of FFA involves follicular micropapules randomly distributed over the facial skin but readily more visible over the temporal regions. No particular inflammatory sign ie, erythema or desquamation is present, and facial vellus are decreased or absent. Proximities, such as inframandibular and retroauricular areas, may also be affected; this may help differentiate FFA from photodamage.

Our patients referred to it as roughening of the facial skin but did not correlate it with their hair problem, usually attributing it to aging or menopause. Histologic testing of facial vellus in these patients showed LLP features similar to scalp FFA and to the body vellus involvement shown in previous studies 1 – 3 and in 2 of our patients patients 3 and 4. Correlation of clinical and pathological findings suggests that follicular papules correspond to inflamed vellus follicles; we recommend that this be the site of a biopsy in suspected cases of FFA.


No topical treatments were prescribed for the face area despite histologic findings of disease activity, but all patients received therapy with oral medications, such as prednisone, 0.

After at least 6 months of this treatment, all patients reported improvement of their facial skin surface and the regrowth of vellus. Similar to other FFA clinical features, the relationship between the change in facial skin and menopause varied greatly in our patients 4 years before or after menopause. The prevalence of this association is not known; however, because 4 patients with generalized FFA were seen in our hair clinic within a relatively short period, we believe it is underdiagnosed.

In conclusion, the concept of FFA as a generalized disease is important for treatment planning and research. Dermatologists must learn to recognize the subtle changes in facial skin surface of patients with FFA and discuss them with the patients, who may attribute this roughness to aging or hormonal changes of menopause.

Further studies are needed to determine the prevalence of skin involvement in patients with FFA. Drs Donati and Romiti had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Study concept and design: Donati, Molina, and Doche. Analysis and interpretation of data: Donati, Valente, and Romiti. Drafting of the manuscript: Donati, Molina, Doche, and Romiti.

Critical revision of the manuscript for important intellectual content: Administrative, technical, and material support: Facial Papules in Frontal Fibrosing Alopecia: Evidence of Vellus Follicle Involvement. Privacy Policy Terms of Use.

Frontal fibrosing alopecia

Demographic and Clinical Features. Back to top Article Information. Expanding the spectrum of frontal fibrosing alopecia: J Am Acad Dermatol. Acute hair loss on the limbs in frontal fibrosing alopecia: Frontal fibosing alopecia associated with generalized hair loss. Postmenopausal frontal fibrosing alopecia: Frontal fibrosing alopecia in postmenopausal women. J Eur Acad Dermatol Venereol. Frontal frojtal alopecia associated with cutaneous lichen planus in a premenopausal woman. Sign in fobrosing access your subscriptions Sign in to your personal account.

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