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Request PDF on ResearchGate | On Jan 1, , S.D. Navaneethan and others published Inhibidores de la HMG CoA reductasa (estatinas) para pacientes en. Request PDF on ResearchGate | On Jan 1, , S.D. Navaneethan and others published Inhibidores de la HMG CoA reductasa (estatinas) para pacientes con. Los inhibidores de la enzima hepática HMG-CoA reductasa (estatinas), pueden indu- cir importantes reducciones en los niveles de colesterol plasmático y por.

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Interacciones medicamentosas de agentes hipolipemiantes: Hypolipidemic agents drug interactions: Franco 1,4Y. Henao 1M.

Monsalve 1,4F. Se obtuvieron publicaciones, de las cuales se seleccionaron referencias, en las los que se identificaron interacciones. To carry out a structures review of drug interactions of hypolipidemic drugs and to assess their clinical relevance.

The following Mesh terms were used: The information was completed with those articles considered to be relevant. Finally, a method was used to assess the clinical inyibidores of the interaction, based on the likelihood of occurrence and the severity of the effect of the interaction.

HMG-CoA reductasa – Wikipedia, la enciclopedia libre

Thirty-three of them were considered of very high risk level 1 and 42 of high risk level 2basically associated to increased risk for rhabdomyolisis. Enzymatic inhibition of CYP was the most common mechanism for these interactions. Of the interactions identified in patients on hypolipidemic drugs, Most of these interactions are attributed to simultaneous use of CYP3A4 inhibitors.

Therefore, statins metabolized through CYP3A4 simvastatin, lovastatin and atorvastatin are the ones with the highest number of clinically relevant interactions. Drug interactions; Rhabdomyolisis; Hypolipidemic drugs.

Similarmente, este efecto se presenta con la colestiramina y la glipizida El diltiazem puede causar un aumento en la Cmax en 3,6 veces y el ABC en 5 veces de la simvastatina y de 3,5 veces el ABC de lovastatina; efecto que no se evidencia en el caso de la pravastatina Estos efectos se deben posiblemente al efecto inhibidor de estos calcioantagonistas sobre la CYP3A4 De igual manera, la ciclosporina aumenta en 3,4 veces el ABC de ezetimiba Adicionalmente, el fenofibrato no presenta interacciones relevantes con colestipol o colesevelam El ezetimiba es bien tolerado y no interacciona con fluvastatinalovastatinarosuvastatina o simvastatina Efecto que no se observa para la pravastatina Interacciones medicamentosas de mayor relevancia en hipolipemiantes.


Por ello, las estatinas metabolizadas por la CYP3A4 como la simvastatina, lovastatina y atorvastatina son las estatinas que presentan mayor evidencia sobre las interacciones, mientras que la pravastatina posee un mejor perfil de seguridad debido a que no es metabolizado por CYP Pleiotropic effects of statins.

Risk for myopathy with statin therapy in high-risk patients. Baycol withdrawn from market. Interactions between statins and macrolide antibiotics. Interacciones medicamentosas en pacientes infectados con el VIH: Fibrates in the treatment of dyslipidemias-time for a reassessment.

N Engl J Med. Severe rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin, amiodarone, and atazanavir. J Am Board Fam Med. FDA adverse event reports on statin-associated rhabdomyolysis.

Ros E, Laguna JC. Tratamiento de la hipertrigliceridemia: Pharmacokinetic interactions between statins and fibrates. Am J Cardiol ;96 suppl 9A: Use and indications of cholestyramine and bile acid sequestrants. Erythromycin and verapamil considerably increase serum simvastatin and simvastatin acid concentrations. Erythromycin coadministration increases plasma atorvastatin concentrations.

Rhabdomyolysis secondary to a drug interaction between simvastatin and clarithromycin. Rhabdomyolysis associated with concomitant use of simvastatin and clarithromycin.

Rhabdomyolysis caused by comedication with simvastatin and clarithromycin. Rhabdomyolysis resulting from interaction of simvastatin and clarithromycin demonstrated by Tcm MDP scintigraphy. Lovastatin-induced rhabdomyolysis reductasx associated with clarithromycin and azithromycin.

A study of the interaction potential of azithromycin and clarithromycin with atorvastatin in healthy volunteers.

Molden E, Andersson KS. Simvastatin-associated rhabdomyolysis after coadministration of macrolide antibiotics in two patients. Multiple organ toxicity inhibieores addition of erythromycin dee long-term lovastatin therapy. Drug interaction caused by communication problems.

Rhabdomyolysis due to a combination of itraconazole and simvastatin. Rhabdomyolysis after concomitant use of cyclosporine, simvastatin, gemfibrozil, and itraconazole. Rhabdomyolysis induced by simvastatin-fluconazole combination. J Natl Med Assoc. A lesson for everyone in drug-drug interactions. Rhabdomyolysis from cytochrome p interaction of ketoconazole and simvastatin in prostate cancer.

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Rhabdomyolysis in a patient receiving atorvastatin and fluconazole. Eur J Clin Pharmacol. Effect of itraconazole on the pharmacokinetics of atorvastatin. Itraconazole drastically increases plasma concentrations of lovastatin and lovastatin acid.

HMG-CoA reductasa

Hepatitis and rhabdomyolysis in a patient with hormone refractory prostate cancer on ketoconazole and concurrent lovastatina therapy. Effect of fluconazole on plasma fluvastatin and pravastatin concentrations. Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin.


Br J Clin Pharmacol. Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole. The effect of fluconazole on the pharmacokinetics of rosuvastatin. Negredo E, Rey-Joly yC. Cardiovascular risk and human immunodeficiency virus infection: A new clinical challenge.

Drug-drug interactions between raltegravir and pravastatin in healthy volunteers. J Acquir Immune Defic Syndr. Pharmacokinetic interaction between nelfinavir and pravastatin in HIV-seronegative volunteers: Pharmacokinetic interactions between protease inhibitors and statins in HIV seronegative volunteers: Simvastatin-nelfinavir interaction implicated in rhabdomyolysis and death.

Rhabdomyolysis due to probable interaction between simvastatin and ritonavir. Am J Health Syst Pharm.

Pharmacokinetic interactions between nelfinavir and 3-hydroxymethylglutaryl coenzyme A reductase inhibitors atorvastatin and simvastatin. Simvastatin coprescribed with protease inhibitors despite dangerous drug interactions. Effect of efavirenz on the pharmacokinetics of simvastatin, atorvastatin, and pravastatin: Interacciones medicamentosas de etravirina. Enferm Infecc Microbiol Clin. Endocrinol Metab Clin North Am.

Gemfibrozil concentrations are significantly decreased in the presence of lopinavirritonavir. Comunicado de la FDA sobre la seguridad de los medicamentos: Oates E, Dzintars K. Interaction between enfuvirtide, an injectable fusion inhibitor, and niacin in an HIV-infected patient. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation: Not all statins interfere with clopidogrel during antiplatelet therapy.

Eur J Clin Invest. Lack of clopidogrel-statin interaction in patients inhibidroes coronary stent implantation. A randomised determination of the Effect of Fluvastatin and Atorvastatin inhividores top of dual antiplatelet treatment on platelet aggregation after implantation of coronary drug-eluting stents. Influence of statin treatment on platelet inhibition by clopidogrel-a randomized comparison of rosuvastatin, atorvastatin and simvastatin co-treatment. Effect of atorvastatin on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in healthy subjects.

Effects of rosuvastatin on platelet inhibition reudctasa clopidogrel in cardiovascular patients. Platelet aggregation inhibition in patients receiving statins either fully or partially metabolized by CYP3A4. Proc West Pharmacol Soc.

Effect of clopidogrel on the steady-state pharmacokinetics of fluvastatin.

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